And tinkering with food oils is no substitute for heart-protecting drugs or sweeping changes in diet.
But an Israeli deal with Syria alone is no substitute for negotiations over the nub of the matter: a direct deal between Israel and the Palestinians.
There is no substitute for communicating intelligently with prospective buyers.
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There can be no substitute for decades of dealing with and solving problems, of survival through hard things, of seeing our own progress in striving to get better at something.
It made no difference though as Dindane immediately linked up with substitute Kanu to make it 3-0.
There is no substitute for an entrepreneur remaining in touch with his or her business, and practicing effective checks and balances in the business.
Kilmarnock had dominated the first half without scoring, and they were made to pay early in the second period when Sodje outmuscled Pascali putting himself one-on-one with substitute keeper Anssi Jaakkola, and he made no mistake, rolling the ball into the net to claim his first Hibernian goal.
But he has emphasised in the past that it is not his job to play cat-and-mouse with the Iraqi regime, and that no number of inspectors can substitute for Iraq's willingness to co-operate in its own disarmament.
As with Mr Morales in Bolivia, constitutional tinkering may prove to be no substitute for governing.
Color Red is no substitute for an Iron Dome defense system, but with as little as 15 seconds between an air defense warning and a rocket striking its target, Color Red offers a little bit of extra time for users to find shelter.
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Simulation has been great, but it is no substitute for hands on work, whether addressing urgent needs with the W-76 or B-61 weapons or proceeding with the RRW, none of which is possible without additional budgetary resources and scientists who can finally get their hands on these kinds of programs.
The fourth goal eventually came courtesy of Welbeck, another substitute brought on by Ferguson, who gave Sorensen no chance with a powerful shot from 25 yards.
In an emergency, employees can apply for small affordable loans through partner banks and credit unions, with their job tenure acting as a de facto substitute for low (or no) credit.
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The very fact that the drug industry has come up with so many genuine lifesavers like antibiotics or cancer drugs for which there is no lifestyle substitute.
The committee's report also details its unhappiness with how schools record the reasons for requiring a substitute teacher, noting that there was "no standard method of recording".
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