Henman will be part of the BBC's commentary team for Wimbledon 2010, which begins on 21 June.
But unlike his clash with Nicolas Mahut at Wimbledon 2010, Isner was beaten 6-7 (7-2) 6-4 6-4 3-6 18-16 in a grueling contest which lasted five hours and 41 minutes.
Federer cantered through the fifth set in 27 minutes, but both players earned deserved standing ovations from a Centre Court crowd as shocked as they were delighted by such a dramatic opening match of Wimbledon 2010.
He begins his campaign against Colombia's Alejandro Falla, the man who took him to five sets at Wimbledon in 2010.
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Then, of course, there was the 11-hour, five-minute circus act, performed over three days, by John Isner and Nicolas Mahut at Wimbledon in 2010.
Arguably his major claim to fame is playing in the longest match of all time at Wimbledon in 2010, though he has beaten Federer and Djokovic.
But her thoughts are on the title, rather than the ranking or the ability to become the first top seed to win a major since Williams at Wimbledon in 2010.
Isner, who was involved in the longest match in tennis history at Wimbledon in 2010, won the game and then broke the Argentine's serve in the next to set up a clash with Spanish 18th seed Feliciano Lopez.
Her three fellow Wimbledon semifinalists had one semifinal appearance in a Grand Slam before today (Kvitova, 2010 Wimbledon).
But the 2010 Wimbledon and US Open finalist responded admirably, winning the second set before wrapping up proceedings in the third in 30 minutes.
However, following more than a year on the sidelines after winning the 2010 Wimbledon title, she now has no substantial ranking points to defend until July.
Nadal prevailed 6-4, 4-6, 6-2 to improve to 16-1 against Ferrer on clay -- Ferrer won their first match in 2004 -- and set up a showdown with Berdych in a repeat of the 2010 Wimbledon final, which Nadal won.
Former world No. 1 Caroline Wozniacki, from Denmark, faces a tricky opening encounter against Sabine Lisicki while 2010 French Open winner Francesca Schiavone plays 2011 Wimbledon champion Petra Kvitova.
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The 24-year-old Shvedova also reached quarterfinals in Paris in 2010, when she won grand slam doubles titles at Wimbledon and the U.S. Open.
He covered Spain's 2010 World Cup victory from Madrid and has broadcast live from Wimbledon, the US Open (both tennis and golf), the Ryder Cup, the Open Championship, the Rugby World Cup, the Tour de France, the Abu Dhabi Grand Prix and five consecutive Champions League finals.
Federer's triumph was his first at Wimbledon since 2009, with his last major win coming at the Australian Open in 2010 when he also beat Murray.
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