The UK Drug Policy Commission said billions of pounds a year were spent tackling drug problems, "without always knowing what difference it makes".
And see what a difference it makes when you finally stop struggling to consume content in that noisy, windy box.
As a military mom, I know what a difference it makes when individuals or groups reach out to show support to service members and their families.
Now, what also makes NASCAR special is the difference that it makes in the lives of so many people, especially our troops and their families.
Guess we can say it again: what a difference a day makes.
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"It really makes a difference what your background is, " says Till Marco von Wachter, a Columbia University economist who has studied the long-term effect of graduating during a recession.
It makes all the difference in the world where your energy is and what chemical form it takes.
It's never wholly clear what makes the difference between a Frank Sinatra and Joan Sutherland and any number of completely capable and fully engaged but decisively not comparable other performers of the same music.
Nearly all the funds either own, or have owned the usual suspects--Cisco, Intel, Microsoft, Hewlett-Packard, Compaq and Dell--it's what else they buy that makes the difference.
"Some of the best new businesses start in recessions because what they have really makes a difference if the market is interested in it, " Challenger said.
For one, the light that falls on your eyes is meaningless because it could mean anything, it's what we do with information that makes the difference, in how we find patterns and associate those patterns with a useful meaning.
But what makes Sorger's method stand out is the difference in how it approaches the problem of scaling to the human body: the Swift scales, where other bicycles may simply get taller without increasing the wheel base.
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It may be just that little bit of extra effort is what makes a difference.
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But they also know that these values, gentle and compassionate as they are, have to be applied in a harsh, uncompromising world and what makes the difference is not belief alone, but the raw courage to make it happen.
"Giving the boxes is such a small thing to do but makes such a difference to the child receiving it - they are delighted with what they get, " added Mrs Parkinson.
His often-contradictory nine points aside, the key to the success or failure of 3D will obviously be whether or not audiences think the difference is consistently worth the money, no matter what anyone says about it -- or how awesome it makes sports look.
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