"To be honest, I'm expecting it to be a big night for Adele, " Werde said.

CNN: Adele unbeatable at the Grammys?

Robertson said she sees the Foo Fighters bringing some heat for the industry darling in the album of the year category, and Werde noted that Grammy predictions are hit-or-miss.

CNN: Adele unbeatable at the Grammys?

That's not to diminish the talents and achievements of the other players who are also in the running, said Bill Werde, Billboard's editorial director, but rather to view "21" as a different beast.

CNN: Adele unbeatable at the Grammys?