Still, Wellbutrin has remained a minor drug, making only about one-fifth the sales of Prozac.
It took the FDA a while, but eventually it confirmed that Budeprion releases its active ingredient much faster than Wellbutrin.
FORBES: FDA Pulls Generic Antidepressant for Ineffectiveness
The nonstimulant amantadine has been used to great advantage in treating ADD, as has bupropion (Wellbutrin) and the newest nonstimulant, Strattera.
The FDA should immediately suspend approvals for generics Wellbutrin XL and advise doctors via a Dear Doctor Letter to switch to the brand.
FORBES: A Drug Recall That Should Frighten Us All About The FDA
The FDA should conduct their own study of the bioequivalence of the other generic Wellbutrin XL it approved and not rely on the drug makers.
FORBES: A Drug Recall That Should Frighten Us All About The FDA
The two drugs are naltrexone, used to treat alcohol and cocaine addiction, and bupropion (known mainly as Wellbutrin), an antidepressant, which also helps people quit smoking.
GlaxoSmithKline, also based in the United Kingdom, has a stable of well-known brands, including respiratory (Advair and Ventolin), antiviral (Combivir) and anxiety (Wellbutrin and Paxil) treatments.
In addition, the atypical antidepressant Wellbutrin can help treat ADD.
So it allegedly paid speakers, like Pinksy, who spoke about how, in his clinical practice, he used Wellbutrin SR in patients who suffered low sex drive on other drugs.
FORBES: Feds Say Dr. Drew Was Paid By Glaxo To Talk Up Antidepressant
In December 2006, the first generic versions of the popular anti-depressant Wellbutrin XL were approved by the FDA. The drug comes in two dosage strengths, 150 milligrams and 300mg.
FORBES: A Drug Recall That Should Frighten Us All About The FDA
Prozac's least-popular side effect is a diminished sex drive, and when patients complain to their doctors, they often end up taking Wellbutrin, which can heat the sex drive back up, in addition to Prozac.
Glaxo Wellcome glx (nyse: glx - news - people) tried the same thing with its antidepressant drug buproprion in 1997, a drug it has sold under the name Wellbutrin since 1987.
Some depression sufferers have not only complained to FDA and consumer advocates about the negative effects of being switched from Wellbutrin XL to its generic, they have sued the generic manufacturers (as noted in this Legal Pulse post).
FORBES: FDA Needs To Address Concerns Over Generic Drug Equivalence
In July Glaxo pled guilty to U.S. misdemeanor charges that it had marketed the anti-depressants Paxil and Wellbutrin for unapproved uses and had not disclosed clinical data related to the diabetes medicine Avandia, which eventually had its use severely restricted because it may increase the risk of heart attacks.
FORBES: With Transparency Pledge, Glaxo Makes Promises No Other Drug Company Has
For the most part, the prescription chatter concerns such familiar brands as Effexor, Wellbutrin, Xanax and Zoloft we're a long way from the Soma of Aldous Huxley's "Brave New World" though special attention is reserved for Ablixa ("Take Back Tomorrow"), a new competitor for market share that's no less effective for being fictional.
WSJ: Pleasure Pill | Side Effects | Identity Thief | Lore | Film Reviews by Joe Morgenstern
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