Their lab work shows squalamine disrupts the membrane interactions needed for viral replication.

BBC: Dogfish shark chemical squalamine 'stops human viruses'

By devising small chemicals that fit into the "active sites" of these proteins and block their function, drug firms hope to stop viral replication.

FORBES: Magazine Article

Koronis CEO Donald Elmer explains that the Koronis drug uses the viral replication process to induce additional mutations in the HIV genome by mismatch base pairing.

FORBES: With Koronis, Is A Cure For HIV On The Horizon?

Traditional HIV drugs attempt to block viral replication.

FORBES: With Koronis, Is A Cure For HIV On The Horizon?