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Andrew Mumford's 52nd-minute strike gave the Welsh Premier side the lead but Vetra levelled within four minutes.
BBC: SPORT | Football | Welsh | Vetra 3-1 Llanelli
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Darvydas Servnas, who was sent off in the last minute for foul play, broke through to bring Vetra level.
BBC: SPORT | Football | Welsh | Vetra 3-1 Llanelli
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However, after a nervy opening half hour, Fulham comprehensively outplayed FC Vetra, who finished third in the A Lyga last season.
BBC: FK Vetra 0-3 Fulham
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And Murphy effectively killed the game off from the spot 10 minutes after the restart after Zamora had been hauled down by Vetra skipper Algis Jankauskas.
BBC: FK Vetra 0-3 Fulham
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Fulham began their Europa League campaign in the third qualifying round with a trip to Vetra in Lithuania on 30 July, and then came through a difficult group which included Italian side Roma and Swiss outfit Basle.
BBC: Fulham boss Roy Hodgson hails striker Bobby Zamora
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It all started nine months ago on a scorching summer's day in Lithuania, where the Cottagers beat FK Vetra in the third qualifying round, before moving on to west-central Russia for the qualifying play-off second leg against Amkar Perm.
BBC: From the Cottage to the Continent
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Zamora, who has scored eight times during Fulham's European odyssey, which began on 30 July against Lithuania side FK Vetra, has not played since the 2-1 semi-final, second leg win over Hamburg on April 29 at Craven Cottage, when Duff was also hurt.
BBC: Fulham manager Roy Hodgson eyes Europa League glory