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Patients' urethras functioned normally within a few weeks after surgery and maintained that function for up to six years.
CNN: Scientists 'seed' cells, make new organs
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Patients had their engineered urethras implanted between March 2004 and July 2007 at the Federico Gomez Children's Hospital in Mexico City.
CNN: Scientists 'seed' cells, make new organs
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In a small pilot study, published Monday in the Lancet, scientists reported successfully reconstructing urethras in five young patients, using their own cells.
CNN: Scientists 'seed' cells, make new organs
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Earlier this year, regenerative medicine scientists at Wake Forest University School of Medicine reported that they had engineered five urethras between March 2004 and July 2007.
CNN: Lab-made organ implanted for first time
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And that is where engineering urethras may offer some benefit.
CNN: Scientists 'seed' cells, make new organs
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Their urethras continued to function after several years' follow-up.
CNN: Scientists 'seed' cells, make new organs
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"Unfortunately for the narrow structures in the body (like urethras), they are kind of complex because they tend to collapse, " said Atala, who added that conventional urethra replacement fails more than half the time.
CNN: Scientists 'seed' cells, make new organs