New techniques used in the study, such as using ultrasound to measure artery plaque, are generally difficult, and not as well understood as cholesterol lowering, they say.

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Steven Nissen, the chairman of cardiology at the Cleveland Clinic and head of the American College of Cardiology, will present one key study that will use ultrasound probes to measure the effect of torcetrapib on plaque in the coronary arteries at the ACC meeting in New Orleans next March.

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In fact, in 2008 a study using ultrasound images of arteries failed to show that the combination of Zetia and simvastatin prevented artery hardening any better than simvastatin alone.

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In a study two years ago, Nissen used the same ultrasound technology to compare Lipitor to Pravachol, a weaker drug made by Bristol-Myers Squibb.

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In a study two years ago, Nissen used the same ultrasound technology to compare Lipitor to Pravachol, a weaker drug made by Bristol-Myers Squibb (nyse: BMY - news - people ).

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Nissen used ultrasound probes to measure the amount of plaque inside patient's arteries at the beginning of the study and again after 18 months.

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