Second-half tries from Joe Gray and Ugo Monye also helped Harlequins to their second straight win.
Ugo Monye's 43rd-minute try cut the gap, but Stade's star-studded side gradually made their class tell.
The Exiles feature England Sevens players Paul Sackey and Geoff Appleford, while Quins include exciting wing Ugo Monye.
Saints led 6-3 via two Stephen Myler penalties before Ugo Monye's converted try gave the visitors the lead.
Rob Kearney, Ugo Monye, Tom Croft and Nathan Hines will make their debuts.
Ugo Monye and Gonzalo Camacho scored tries while Varndell crossed twice to give Wasps a 16-15 lead at the break.
Mark Cueto moves to full-back, with Ugo Monye switching to the wing.
Wing Ugo Monye needs an early touch to get rid of any nerves that might be around with it being his debut.
And with fellow wingers Paul Sackey injured and Ugo Monye on Lions duty he staked his claim with a performance that impressed Johnson.
The Wales wing, 32, has seen Tommy Bowe and Ugo Monye move ahead of him in the Test berths to face South Africa.
"I didn't think I would get this chance, " said Ashton, who will come into the England team for injured Harlequins winger Ugo Monye.
But soon after the restart England cut loose with a cracking try as Easter, Ugo Monye and Armitage combined to send Tait racing over.
Jamie Roberts, Ugo Monye and Tommy Bowe scored two tries each, with Brian O'Driscoll, Tom Croft, James Hook and Stephen Ferris getting the others.
But victory came at a cost for the visitors when star wing Ugo Monye limped off with an ankle injury on the half hour.
Visiting Quins scored four early tries through Simon Keogh (twice), Ugo Monye and Chris Malone - but three missed Malone conversions left the door ajar.
Ronan O'Gara's second penalty and conversion of Ugo Monye's fortuitous try eased the Lions' nerves, and a penalty try with 11 minutes left settled the outcome.
Number eight Tony Diprose, a colossus in defeat against Sale, may receive offers from other Premiership clubs, too, while young winger Ugo Monye will also be tailed.
BBC: SPORT | Rugby Union | Quins must focus on business of rugby
The All Blacks then exploded into life with a dazzling attack from a line-out but Ugo Monye's despairing tackle was enough to just force Mils Muliaina into touch.
Johnson's other wing options in the second-string England Saxons are Topsy Ojo, who made his Test debut in New Zealand during the summer, Ugo Monye and Matt Banahan.
Ugo Monye, dropped after the first Test defeat, returns on the right wing, with world player of the year Shane Williams starts in place of Fitzgerald on the left.
England wing Ugo Monye added a third after the break when he snatched a stray pass deep in his own half and raced 70 metres to score under the posts.
England wing Ugo Monye is also on the plane, but national captains Steve Borthwick of England, Ryan Jones of Wales and Mike Blair of Scotland were among those left out.
With Lewsey also departing, Ugo Monye - promoted from the second-string Saxons last week to replace the injured James Simpson-Daniel - could start on the left wing against the Pacific Islanders.
Byrne will have the reassuring presence of his regular Ospreys team-mate, the "on-fire" Tommy Bowe, alongside him on Saturday, with England wing Ugo Monye completing a back three full of attacking potential.
The Blues went ahead for the first time when Ugo Monye's kick failed to find touch and was gathered up by Tom James, who off-loaded to support runner Spice, who touched down.
Once again, they seemed to prefer to kick rather than run with the ball, while Ugo Monye, playing out of position at full-back, looked like a fish out of water until switched to the wing.
But they recovered to make it six wins out of six courtesy of a Ugo Monye try, a penalty try and 10 points from substitute fly-half Ronan O'Gara who kicked two penalties and two conversions.
Sunday was our one full day off together this week and Ugo Monye has been charged with telling us the things to do, and not to do, each time we turn up at a new location.
They will have to perform not just up front but also behind the scrum, where they need to release the real talent they have in the back three in Delon Armitage, Ugo Monye and Paul Sackey.
Will Skinner was denied a try by the arm of Juan Leguizamon and Ugo Monye's footballing skills deserted him when he raced onto Evans's astute chip, and the near misses nearly came back to haunt the hosts.
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