Mathis walked with two outs, and scored when Fernandez lined a single into deep left-center.
The Mariners chased Hughes (2-3) after he got only two outs in the first.
With two outs, pinch hitter Ben Francisco grounded out to third and stranded Nelson.
Cory Gearrin hit John Buck with a pitch to load the bases with two outs.
With two outs, Lee hit a sharp single up the middle to score Mayberry.
Harvey walked Quentin with two outs in the seventh as paper wrappers swirled around the field.
Murphy came up with the bases loaded and two outs in the eighth against A.J.
Halladay struck out Melky Mesa with the bases loaded and two outs in the first.
The right-hander did not give up another hit until Paul singled with two outs in the fourth.
Two outs later, Francisco homered to left for his first RBI in 30 at-bats with the Yankees.
At 2-all in the ninth with a runner on first and two outs, the Mets challenged the All-Star.
Walden, who began the night with a 1.54 ERA, gave up two runs while getting just two outs.
The right-hander changed that by not giving up another hit until Paul singled with two outs in the fourth.
With two outs in the seventh inning, rookie Juan Lagares connected off Wood for his first big league homer.
The lone hit was Ruben Tejada's infield single to score the tiebreaking run with two outs in the 15th.
Toronto brought in lefty reliever Brett Cecil to face the lefty-swinging Hafner with two outs and Wells on third.
Harvey was cruising along until he walked Adrian Gonzalez on a full-count pitch with two outs in the sixth.
Two outs later, Cabrera capped the rally with an RBI single to right.
The Mets scored five runs in the fourth off Gonzalez with two outs.
'It has been a long time since I've seen any team get six hits in a row with two outs.
In the second, Nate McLouth singled with two outs, stole second and took third on Machado's single off Kuroda's leg.
The Yankees stranded three runners at third base but each time there were two outs when the runner got there.
Pujols homered with two outs in the first and Trumbo led off the second with his fourth of the season.
Shawn Kelley (1-0) got two outs in the 10th for the win and Mariano Rivera finished for his fifth save.
With the bases clear and the Yankees two outs away from a loss, the situation called for a long ball.
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The powerful Mets were down to their last chance in the '86 Series when Carter stepped up with two outs.
Jordany Valdespin beat out a bunt with two outs in the Mets' third and scored on a headfirst slide on Murphy's double.
The Astros had 17 hits in improving the AL's worst record to 8-18 and scored their first five runs with two outs.
Imagine there are two outs, bases loaded, in a close playoff game.
The Lions (28-20) scored five runs in the eighth inning to erase a 5-0 deficit, getting the last three runs with two outs.
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