In trials among 2, 500 needle users in Thailand, placebo and vaccine will be divided evenly.
Onyx has data showing that Sorafenib slows tumor growth, compared with a placebo, but in late-stage trials only 2% of patients had their tumors shrink enough to be counted in the response rate.
Flurizan completed Phase 2 human trials in Alzheimer's patients, and it is also in Phase 2-b human clinical trials for treating patients with pre-metastatic prostate cancer.
PDA-001 will soon be the object of multiple, larger Phase 2 trials across several diseases.
Merck has started randomized Phase 2 trials in 240 patients in colon cancer.
The current Phase 2 trials -- testing whether the vaccine is effective -- have been enrolling patients only since last summer.
McDonald suggests one likely target: Albuferon, an interferon drug for hepatitis C now in phase 2 trials that belongs to Human Genome Sciences.
McDonald suggests one likely target: Albuferon, an interferon drug for hepatitis C now in phase 2 trials that belongs to Human Genome Sciences (nasdaq: HGSI - news - people ).
One in which it has expressed some interest is in Neu Vax, which recently completed phase 2 clinical trials as a vaccine for breast cancer patients.
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The day before the opening today of the ASH conference in Atlanta, TG Therapeitics announced it has initiated a phase 1 and 2 clinical trials to evaluate the safety, tolerability and efficacy of its product, TG-1101, a novel third-generation anti-CD20 monoclonal antibody, in combination with Revilimid for patients with relapsed or refractory B-cell lymphoid malignancies who were previously treated with anti-CD20 antibody therapy.
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The U.S. government lists 2, 496 clinical trials of stem cell-based medicines.
Novartis (nyse: NVS - news - people ) is conducting similar trials for its experimental Cox-2 drug, still known by the codename Cox-189.
Apart from its anti-cancer drugs Fusilev and Zevalin, Spectrum has 10 other oncology drug candidates that are now in clinical development, two of them in phase 3 clinical trials and several undergoing phase 1 and 2 clinical studies.
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Lilly's two trials of solanezumab looked at a total of more than 2, 050 patients over an 18-month treatment period.
In stark contrast to ImClone, which rashly tested Erbitux in only 120 patients with no control group, AstraZeneca enrolled 2, 000 patients in late-stage trials to compare how long patients survive on a combination of chemotherapy and Iressa versus chemo and a placebo.
The long timelines for drug development stem from a large number of factors, but one of the key reasons is that the FDA, largely in response to major drug problems with drugs like Rezulin and the Cox-2 inhibitors, has required larger and longer trials.
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Amylin Pharmaceuticals (nasdaq: AMLN - news - people ) is in phase III trials of Exenatide, a drug that promises to treat Type 2 diabetes.
She has revived her injury-marred career since giving birth last February, and she ran a 2:41 marathon in September to qualify for the trials.
Novartis (nyse: NVS - news - people ), which is developing a Cox-2 drug called Prexige, has decided on even bigger clinical trials than Merck.
Novartis' response to the concerns that Cox-2 inhibitors might cause heart problems is to run extra clinical trials to try and prove that its drug does no cardiovascular damage.
Moreover, he says, based on data from other randomized, controlled trials, he doesn't see big differences between any of the COX-2 drugs.
However, in the case of Nexavar, Phase III clinical trials with 602 patients showed that it extended the life of the average patient by 2.8 months to 10.7 months, as compared to patients who received a placebo.
Plus, successful clinical trials of new drugs routinely show a benefit on such metrics over a 1- or 2-year period.
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Had the company instead tested Herceptin on a broad range of patients, its trials likely would have failed because most breast tumors aren't driven by HER-2.
It has been conducting trials with 1, 500 machines in the region and has begun to distribute a further 2, 100 to a school in Rafah, in the south of the Gaza strip.
The safety and efficacy of Belviq were evaluated in three randomized, placebo-controlled trials that included nearly 8, 000 obese and overweight patients, with and without type 2 diabetes, treated for 52 to 104 weeks.
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Bextra, another Cox-2 inhibitor made by Pfizer, increased the risk of side effects, including heart attack in trials of patients undergoing heart surgery.
The drug, still undergoing clinical trials in the U.S., seems to have the same side effects as the other COX-2 inhibitors, but in tests against morphine, ketorolac (Toradol) and a placebo, Dynastat was superior to morphine and the placebo and comparable to ketorolac in potency and duration.
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