Drug companies such as Roche and AstraZeneca have explored using the cells to detect toxic side effects.
That could limit the toxic side effects of some treatments, while simultaneously being more effective at fighting disease.
One way to do that is to increase the effectiveness of old chemotherapy drugs by reducing toxic side effects.
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The new drug consists of just the active portion of that drug to eliminate toxic side effects such as bowel inflammation.
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Like many other cancer drugs, it does have potentially toxic side effects, but analysts expect it to be a multi-billion dollar seller.
D.s and 75 veterinarians test drugs in preclinical development on healthy rodents (looking for toxic side effects)and on sick ones (looking for cures).
Skeptics questioned whether it was possible for such drugs to avoid causing toxic side effects and shutting down important functions in healthy cells.
Treatment, which can have toxic side effects, is expected to continue for infected patients for "many months, " Dr. John Jernigan told reporters this month.
Ms. Skipper's new regimen came with painful, toxic side effects.
Adams' team of 35 scientists spent two years tinkering with dosages to reduce toxic side effects, settling on twice-weekly injections that slowed tumor growth in mice but didn't kill them.
By blocking these errant molecules, D-serine and poly ADP-ribose polymerase (PARP), researchers may be able to stop brain cells from dying while avoiding the toxic side effects that have plagued previous experimental treatments.
By blocking these errant molecules, called D-serine and poly ADP-ribose polymerase, known as PARP, researchers may be able to stop brain cells from dying, while avoiding the toxic side effects that have plagued previous experimental treatments.
Encouraging data are also expected this weekend for an approach in which potent doses of chemotherapy are linked to antibody drug such as Roche's Herceptin to deliver chemo more directly to the tumor like a guided missile, to reduce the toxic side effects of chemo.
The compound appears not to show any toxic side-effects, although much more safety testing will be needed.
There was a problem: T67 passed easily into the brain, a fact that was great for treating brain cancer-- but one that also caused the drug to have toxic neurological side effects at high doses.
Just a few years ago researchers had naively hoped that they could design a drug to blast a single cancer-causing protein and send the disease into remission for years without forcing the patient to endure the side effects of prolonged toxic chemotherapy.
If these certain enzymes cannot break down the medications, the drugs can become toxic and lead to serious and deadly side effects.
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