Hepatitis C drugs are tough to take, causing flu-like side effects and anemia.
"For me to know this is my last Six Nations is tough to take, " said Williams, who has scored 51 Test touchdowns.
On Thursday, shortly after Pistorius was charged in South Africa with the shooting death of his girlfriend, model Reeva Steenkamp, the mayor of Gemona said it was tough to take.
Iurie, a young man with dark stubble on his face, looked tough enough to take care of himself.
Losing in June is tough enough to take, but being shown the door in late April is almost inconceivable.
Those concerns dissipated once Caroline showed she was tough enough to take the rough and tumble of the game.
Even with Big Media on its side, iPod challengers will still face a tough battle to take significant market share from Apple.
He's tough enough to take the club forward in his own style.
Friends of the Earth said it had studied reports produced on air pollution in Scotland's four major cities last year and found most would fail to reach tough targets due to take effect in 2005 to cut levels of nitrogen dioxide, which is emitted by cars.
However, losing to unseeded Craybas was still tough for Williams to take and she had to wipe away tears in the press conference that following her defeat.
Many people in the cities, however, want the authorities to take tough measures in order to improve their quality of life.
And it's going to take some tough decisions to close those gaps.
We will use online and offline advocacy tools to build support for policy changes, and we will strongly support those willing to take the tough stands necessary to promote these policies in Washington.
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There have been signs of differences in the Bush administration over how tough a stance to take.
"We had a tough time trying to take the U.S. national pastime to court in the U.S., " he says.
They fought back from a tough start to briefly take a third-quarter lead before James led the onslaught that sapped the energy from what had been a lively crowd for the nationally televised game.
We simply need to make these tough choices and be willing to take on our bases.
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The Department for Education (DfE) said schools were expected to take a "tough line" on requests to miss lessons.
If governments are to be able to take the often tough and unpopular decisions needed to promote economic growth, they must start with unquestioned legitimacy.
Once he begins his term of office, presuming that he wins, Mr Putin may be able to take the tough decisions he frequently demands but has been unable, so far, to define.
So we told them, if you're willing to take the tough and painful steps you make -- that are needed for you to become more competitive, then we're willing to invest in your future.
Even Google Glass, which actually does appear to be a dramatic leap forward in the way we interact with computers, is bound to be a tough sell that could take years for the population to acclimate to.
The sharp swing in sentiment from the financial media is tough for most investors to take.
The other members of the Security Council will have no doubt about America's determination to take tough action.
You know, I appreciate him going out, doing the town hall meetings and talking with voters, willing to take tough questions.
But, equally, a majority of Labour voters see Mr Miliband as strong and determined and willing to take tough but unpopular decisions.
Damian Allen, executive director for children and family services, said it was "an immensely tough decision for us to take" but was unavoidable.
Rossiter said the decision was a tough one for Batchelor to take, but he was impressed with his reaction when he gave him the news.
Its candidate Hugh Annand said the result was "extremely disappointing but perhaps not surprising" given that the Lib Dems were in government and having to take tough decisions.
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