The Cleveland Clinic's Eric Topol explains why he advised a fund that sold Merck short.
In a separate interview Thursday, Lanier confirmed that he does have a relationship with Topol.
Topol also provides his results for a consumer drug-response test provided by Pathway Genomics.
In his article, Topol points to data from a pivotal 2001 studyof Natrecor conducted by Colucci.
"It's one thing after another, " says Eric Topol, chief academic officer of Scripps Health.
Eric Topol is a prolific tweeter, but he rarely seems interested in cardiology these days.
Cleveland Clinic cardiologist Eric Topol says the number of injured parties could go as high as 160, 000.
When Nissen got back to Cleveland, he showed the results to Eric Topol, the clinic's top cardiologist.
"Neither of these tests is going to be used, because they are genes in isolation, " Topol says.
"A hundred dollars a month and going nowhere fast--there's a lot of people like that, " says Topol.
There are now more cell phones in the world than there are toilets and toothbrushes, Topol said.
"Both the initial treatment that addresses the root cause and the follow-up can be revamped, " Topol said.
This disruption, said Topol, will be characterized by the personalization of drugs, devices, screening tests and treatments.
Topol's JAMA editorial also suggests changes to the Food and Drug Administration that could prevent future drug disasters.
If this happens, "coronary disease may, for all intents and purposes, be history in 20 years, " Topol says.
Lanier said he disclosed his relationships with Topol in court because he had an obligation to do so.
Eric Topol of Scripps Health says his concerns would be the same whatever the outcome of the study.
"This is the first gene-targeted medicine in cardiovascular disease, " says Cleveland Clinic's Topol, who is helping design the trial.
To get those results, however, Wolfe defined "serious heart problems" much more broadly than others--including Topol--have in the past.
After the US helped Russia dismantle obsolete ICBMs, Moscow replaced some of them with the advanced SS-27 Topol-M.
Until last December, Topol held the titles of chief academic officer and provost.
Topol has not been the only doctor pulled into the Vioxx legal proceedings.
Topol played a key role in establishing the Clinic's Lerner College of Medicine.
Topol, the clinic's top cardiologist, is even more negative on the AtheroGenics study.
"We are at a pivot point when it comes to cancer, " Topol observed.
Topol responded late Wednesday that he still works for the Cleveland Clinic, and that his future there has not been determined.
The book also provides colorful anecdotes about Dr. Topol's own sampling of these products, as both a doctor and stand-in patient.
Dr. Topol worries that doctors will resist technologies that empower patients because the tools will also diminish the doctors' gatekeeper role.
Topol, in particular, dreams of a day when tests for genes will be used to determine which drugs a person gets.
Eric Topol , the top cardiologist at the Cleveland Clinic, notes that previous studies suggest naproxen might have had a heart benefit.
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