With Dieng on the bench, Southerland, who had just one basket in the first half, then drained a 3 from the top of the arc to give Syracuse just its second lead of the game.
Singler (14 points) each made a 3-pointer before Johnathan Loyd capped the 25-8 run to end the half with another from the top of the arc in the final seconds, lifting his hand in the air after giving Oregon a 35-19 lead at the break.