Prop Kevin Yates, lock Tom Palmer and back-row James Haskell are the unfortunate forwards to miss out.
Stade Francais lock Tom Palmer, who has trained with the team all week, comes onto the replacements' bench.
Lock Tom Powell was also injured and will have scans on Tuesday to determine the extent of the damage to ankle ligaments.
Other top performers making appearances at this year's festival include Andy Parsons, Sean Lock, Tom Stade, and Marcus Brigstocke.
Connacht hooker Sean Cronin, 23, and Leinster fly-half Jonathan Sexton, 24, could also win their first caps having been named on the bench, where they are joined by Ulster prop Tom Court and Leinster lock Leo Cullen.
But Daniel Leo and Tom Voyce scored while sin-binned Falcons lock Jason Oakes was off the field and Tom Rees added another before half-time.
And they profited from the man advantage with a sweeping move to take the lead, Flutey's dynamic break and Tom Voyce's pass allowing lock Skivington to stretch over.
Scrum-half Tom Slater's sniping run was supported by lock Paterson, with Sweeney on hand to break a tackle and cross for a try he then converted.
Up front, Ulster's Tom Court gets his chance at loose-head while lock Leo Cullen and Denis Leamy are promoted.
With Steve Borthwick installed as captain, Simon Shaw, Nick Kennedy and Tom Palmer are fighting for the one remaining berth at lock.
Andrew and his coaches have opted not to take a look at London Irish lock Nick Kennedy, Northampton hooker Dylan Hartley, Leicester flanker Tom Croft or Wasps centre Dominic Waldouck, the only members of the squad not to feature in either Test 22.
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