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Jamie Roberts, Ugo Monye and Tommy Bowe scored two tries each, with Brian O'Driscoll, Tom Croft, James Hook and Stephen Ferris getting the others.
CNN: Rampant Lions fire rugby Test warning
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Ireland's forwards are again their main strength, but their are some rays of hope in their weak backline of recent years with the inclusion of centre Brian O'Driscoll and scrum-half Tom Tierney.
BBC: News Online
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Seven players drop out from the 34-man squad announced for the short training spin in September, with Tommy Bowe injured and Peter Bracken, Tom Court, John Fogarty, Alan Quinlan, Mick O'Driscoll and Rob Kearney not required.
BBC: SPORT | Rugby Union | Irish | Flanker Ferris in Ireland call-up
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The quartet of Leinster players - O'Driscoll, Rob Kearney, Luke Fitzgerald and Jamie Heaslip - plus Leicester's Tom Croft and Harry Ellis and Northampton prop Euan Murray were rested for the opening match after their exertions last weekend.
BBC: Earls given nod for Lions opener