We all go through periods of not making good money, through job setbacks, life circumstances, or the economy.

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Rather, it happens through a series of setbacks and failures and experiments that ultimately lead to something great.

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Setbacks have proved few and far between, going through 2010 unbeaten with her Commonwealth gold in India a particular highlight.

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The prime minister has suffered a nightmare few months, with Labour slipping behind the Tories in the polls and suffering a series of political setbacks, from the cash-for-peerages row through the John Prescott affair, to the string of Home Office crises.

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In June, 60 drivers took theirs through the Rocky Mountains, where they climbed and descended steep passes, suffering setbacks no more serious than the occasional overheated radiator.

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Microbocides, which are topical, do not carry the same risk of unforeseen setbacks or hidden side-effects as do internal drugs, which have to navigate through the body's entire system, so if VivaGel has made it this far, it's hard to imagine a real failure further down the line.

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