That's a whole lot of agony, and it affects three times as many women as men, largely because the ups and downs of our hormones seem to make us more susceptible, according to Andrew Charles, M.

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Marc Katz, 34, co-founder of online T-shirt printer CustomInk, who learned what it was like to live with the ups and downs of starting three different businesses, from father Steve Katz, 62.

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The year 2011 was one of the most volatile ever for stocks, with ups and downs nearly as severe as during the financial crisis of three years ago.

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