The idea is that the drug delivers the chemo to only the cells with this protein.
FORBES: Celldex Therapeutics Breast Cancer Drug Shows Strong Results In Some Patients
Their tests showed that none of the brains had abnormally high levels of this protein.
They then manipulated this timer by making the virus acquire this protein too fast.
This protein is part of a natural "clean-up" process that kills cells which have become damaged.
Gleevec blocks this protein but only when a flap on the protein is in the closed position.
They then tested drugs to see which might be effective in blocking the action of this protein.
Dr Shimomura, who worked at the Marine Biological Laboratory in Woods Hole, Massachusetts, isolated this protein in 1962.
This was controversial at first, but Slamon persuaded Genentech to test a monoclonal antibody that would block this protein.
Asian people tend to have a high level of "good" cholesterol because they carry a defective version of this protein.
This protein is known also to accumulate in the neurons that degenerate in the brains of people with Alzheimer's disease.
Over the next few years researchers discovered that this protein is a growth regulator in organisms from fruit flies to humans.
Doctors told her she could never take interferon again-a big problem because the main hepatitis C regimens all use this protein.
In 2008, after plotting levels of this protein for two years, he saw a dramatic increase in less than a year.
Because this protein is on the outside of the virus, it is the one that most commonly stimulates an antibody response.
This protein spurs the body to produce crucial inflammatory molecules called leukotrienes, which had been thought to be involved mainly in asthma.
For Myriad, this protein is a new drug target--that is, a chemical targeted to stop the protein might make an effective drug.
Thus a cancer cell stupid enough to be carrying this protein on its surface is going to have a difficult battle on its hands.
FORBES: Exciting New Breast Cancer Drug Poised to Break the Bank?
His lab showed this protein to be the receptor for VEGF, and that blocking the receptor stunted the growth of tumors in lab animals.
This protein - which is produced naturally in jellyfish - is commonly used in this area of research to monitor the activity of altered genes.
They found higher levels of this protein in drug-resistant cancer samples.
In subsequent studies, she unravelled how genetic mutations in this protein cause a rare inherited condition, known as neonatal diabetes, in which patients develop diabetes soon after birth.
Pfizer 's ( PFE - news - people ) Sutent, a drug that blocks this protein, the tumor shrank, according to a report in Nature.
Boys with Duchenne muscular dystrophy lack this protein, called dystrophin.
This protein then produced a two-pronged attack on the cancer.
The molecules of this protein are more or less globular, and are held in that shape by internal cross-links between different parts of the amino-acid chain of which the protein is composed.
On the other hand acquiring this protein too slowly would give the immune system time to launch a response before the virus can escape - killing the virus and preventing infection, they said.
This protein (a member of a group called the lectins, that is being tested for insecticidal properties) was already known to be bad for the immune system, so its effect on the rats would hardly have been a surprise to anyone with a knowledge of the field.
应用推荐