Allen began thinking about a big neuro-science project in the late 1990s, while he was making a flurry of investments in Seattle biotechnology companies.
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"Jack Hanley brought big-league thinking to a nonprofit industry, " says Douglas Tieman, head of the Caron Foundation, a Pennsylvania treatment center.
Now he finds himself hurrying to make up for lost time and thinking big as he taps investment-banking, legal and accounting expertise worldwide.
And co-founder Ruzwana Bashir is thinking big.
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"I remember thinking 'blimey, this guy is big' - but he was good as well, " Newman told BBC Sport.
At least one big institution has been thinking of shutting its credit-research department.
Faced with higher energy costs and little hope of labour-market reform, other big companies are also thinking of leaving Sweden.
Every game will be big - but we will go into them thinking we can get three points wherever we go.
Avaya, in turn, gets to link up with a big brand name that is known for being forward-thinking.
The big question I have about Inbox is whether the developer-level thinking is inline with how its users will actually behave.
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Although the process is being tested on a small-scale right now, project lead and University of Warwick engineering professor Jan Baeyens is thinking big.
Also, having said that, I have big new news for you, we are thinking right now to have a new Islamic-Jewish center, or possibly Islamic-Jewish-Christian center.
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