Patients who had hemodynamically significant lesions as assessed by FFR were then randomized to PCI or OMT.

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Then when a randomized trial showed that hormonal replacement therapy actually raised the early risk of heart attack, women were understandably upset.

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And then this guy named Rajeev Motwani and others started to push the use of randomized algorithms, not as a weird corner case, but the way to do algorithms.

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