It suggests that once a complicated mechanism involving a lot of different proteins has evolved, it is then difficult to change one bit without upsetting the rest.
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The stock loses out on liquidity and subsequent fund raising then becomes difficult.
Now 23, Alrawi was just a young girl before the 2003 U.S.-led war in Iraq that toppled Saddam Hussein, but she still recalls that the most basic international brands were then prohibitively difficult to buy.
And as the father of two children, obviously, it breaks my heart to think about children who have been vulnerable, have probably already gone through difficult situations and then are subjected to even more difficult situations in the past.
If our spirit is not the same as Southend's, then it's difficult, but if our spirit is the same then we have good chance because we have better players than Southend.
If people feel capable, then they see difficult problems as positive challenges and opportunities to succeed.
Republicans and Democrats agreed then to postpone difficult decisions on spending until the end of 2012.
Among all these factors, one simple fact remains: if your best players are missing then it is difficult.
Back then it was difficult for many outside the financial markets to see the potential risks for the global economy.
Generosity in a leader is more important then ever in difficult times.
If spaces designated for casual interaction are visually isolated or not along natural circulation patterns then it is difficult to casually use them.
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It said that if the stand-off was not serious enough to invoke the clause, then it was difficult to imagine what could, "short of all out war".
The German government will then face some difficult choices.
"If we start with the actions next week, which we intend to, to move from a conceptual discussion to implementation phase, we'll start to make commitments that then become very difficult to come out of, " he said.
And then I will let Alan go back to his important and difficult work, and then I will remain to take questions on other subjects.
Then we had some difficult races, especially myself but also as a team where we struggled.
Then it is very difficult to access services which are close enough for them to get to.
Groupon would then profit from its own IPO and the valuing the stock then becomes even more difficult in a traditional sense.
If I get a break with the weather I have a good chance of breaking the record, but if the weather turns against me then it will be difficult.
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In one sense this is obvious: if mining and oil companies reveal the royalties they are paying poor countries then it is more difficult for the politicians in such countries to steal the money.
But then China made life difficult for WikiLeaks and so four years later, Assange and his colleagues declared war on the US, rightly assuming that unlike China, the US would take their attacks lying down.
Fulham began their Europa League campaign in the third qualifying round with a trip to Vetra in Lithuania on 30 July, and then came through a difficult group which included Italian side Roma and Swiss outfit Basle.
It went on: "If this extra income does not rise at least at the same rate as student and staff numbers then it will be difficult to maintain the premium services that the university and colleges provide (and which are essential to preserve the character of Cambridge)".
"At this stage then it becomes acutely difficult, if not quite impossible, to set a budget and precept which is acceptable without causing a severe level of disappointment within the police service, difficulties amongst our partners and anger from the public that we exist to serve, " Mr Michael said.
But then, it is quite difficult to find out what agenda it has at all.
Fine to make that argument but it does then raise a rather more difficult one.
Joe the Plumber made headlines during the 2008 presidential campaign by asking then-candidate Obama a difficult question.
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Well if the first one was so difficult to vote then what makes anyone think a second one will be voted?
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