It was not the first time data from the WHI trials have hurt Wyeth.
The WHI survey also showed that within five years from stopping HRT, the breast cancer risk returns to normal.
In the WHI study, tens of thousands of patients were randomly assigned to either take Prempro or a sugar pill.
That leaves women and their doctors to make tough decisions with even more limited information about what the WHI means.
Since the WHI results were unveiled in July, other drug companies have tried to grab patients who have stopped taking Prempro.
The WHI trials were meant to indicate whether the drugs had a long-term benefit beyond treating the symptoms of menopause, where they are effective.
This summer, an earlier reading of the WHI trials showed that estrogen drugs might be harmful to the heart and might also cause an increase in breast cancer.
Judith Hsia , a cardiologist at George Washington University who was one of the principal investigators in the WHI study, expressed surprise that Wyeth had also chosen to add a warning to the label of Premarin.
But under the glare of the gigantic Prempro trial--part of a set of studies, called the Women's Health Initiative (WHI), run by the National Institutes of Health (NIH)--those benefits evaporated.
Now, another WHI study, examining the risks and benefits of Premarin, has been stopped a year ahead of time.
But Wyeth was unable to release any details because the study, part of a large set of clinical trials called the Women's Health Initiative (WHI), has not yet been published.
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