The study on "good" cholesterol may help doctors predict who is most vulnerable to heart disease and stroke, which are the leading causes of death in the United States.

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This study is another reminder that the effect of a drug on cholesterol levels may not predict what happens to patients.

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"The biggest implication from this particular study is that we were able to actually predict repellency based on models, synthesize compounds, test them in the laboratory, and get good agreement, " Bernier said.

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