However, after extensive studyofthe library's conception and construction I have become convinced that irreversible changes of this magnitude should not be made in this landmark building.
Thestudy, published in 2009 in one ofthe journals ofthe Public Libraryof Science, PLoS Computational Biology, also showed that patients who developed diseases that tend to coincide with many others were more likely to die sooner than people whose diseases were more tangentially connected.
Through his unexecuted project for the facade, a little known study for the tombs of Medici popes Clement VII and Leo X, and studies for the Laurentian Library, Michelangelo transformed himself from a painter and sculptor into an architect.