To make their SIDS model they tweaked this switch so that it came on when themice were three weeks old (mice are born prematurely, relative to people, so that corresponds roughly with the moment of human birth) and then looked to see what would happen.
In an in vivo model using severe combined immunodeficient mice, subcutaneous tumors were generated by inoculating the animals with cells from human non-small cell lung carcinoma cell lines.