On to the minor point first, then the major one.
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The present recession, the first major one in the age of globalization as we know it today, be even more tragic if that vision is set aside just when parts of the developing world are not just about catch up and but are about to spring into the lead, economically speaking.
The magnitude-6.3 quake is the deadliest to strike Italy in decades and the first major one to strike the country in almost seven years.
Another virtue: Although America has had numerous third parties, the current system invariably sees one of the major parties in one way or another co-opting issues that third parties advocate.
More than 14, 000 runners started the race, the first major one put on by the New York Road Runners since their signature event, the New York City Marathon, was canceled by Superstorm Sandy.
The BCC's survey, which it calls the EU Business Barometer, is the first major one of British business since the prime minister's policy speech on Europe.
One of the major findings of the Review of U.S. Human Spaceflight Plans Committee, appointed by the White House, was that the international framework of cooperation for the ISS was one of the major successes of the program.
While America has had numerous third parties, the current system invariably sees one of the major parties co-opt, in one way or another, issues that third parties advocate.
Another virtue: While America has had numerous third parties, the current system invariably sees one of the major parties co-opting, in one way or another, issues that third parties advocate.
The president was conspicuously silent on the one major issue that has dominated national attention for the past week: allegations that he had sexual relations with former intern Monica Lewinsky and that he encouraged her to lie about it under oath -- charges he has vehemently denied but upon which he's offered no further details.
The Soviet invasion of Afghanistan in December was also one of the major stories of 1979 and, like the others chronicled in "Strange Rebels, " one that was historically significant in ways not apparent until later.
So, if Apple were to act in the ethical manner that is being urged upon the company one of the major effects would be to screw over their competitors.
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Heading into the end of the year, one major focal point for the market place will be the so-called U.S. fiscal cliff tax and spending issues that the U.S. administration and Congress must address.
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Extension of the highway was one of the major infrastructure projects planned between 2011 and 2016.
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The class issue is one major reason the Titanic disaster has always been so ripe for dramatization.
Hedge funds, endowments and family offices also piled in making the gold story one of the major themes among sophisticated investors.
The Kukis, one of the major tribes in Manipur, have previously clashed with other Indian separatist groups from the Naga tribe over demands for a homeland.
The award is one of the major publishing events of the year in the UK. Previous winners have included Bill Bryson, Stephen J Gould, Roger Penrose, and Stephen Hawking.
The paper revealed that in the region, one of the major factors predisposing young people towards violence is the mismatch that exists between their aspirations and the opportunities available to them.
Speaking on French radio on Tuesday morning, Foreign Minister Alain Juppe said that Monday's plan was "precisely the response to one of the major questions of this ratings agency that mentions the insufficiency of European economic governance".
The second is that one of the major uses of communication in humans is to try and get sex.
Financial inclusion, say enthusiasts for the scheme, is one of the major ways the identity number can change India.
Michel Murr, the interior minister, both administers the elections and leads one of the major factions competing in them.
The pharmacy producing the drug was not one of the major pharma companies.
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It is no small irony that the thoroughfare which forms one of the major frontlines here is itself called Syria Street.
The country is still one of the major remaining holdouts from Facebook domination, thus representing a huge, untapped market of new users.
The brutal truth is that even massed together, SMEs may never be able to match the pull of even one of the major tycoons like Marimutu Sinivasan, Aburizal Bakrie or Anthony Salim.
The Sepulveda Pass is one of the major mountain passes within the City of Los Angeles, connecting the San Fernando Valley with the west side of the city through the Santa Monica Mountains.
Five years ago, I would have told her that we, the Big Pharma company, are making the major commitment here, one that will perhaps involve the investment of both resources and money.
The one major flaw with social-networking sites is that it all depends on your network.
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