The Welsh region lost 15-24 at home to Overmach Parma to drop into the second tier Challenge Cup, but did make the semi-finals of the competition before losing to Clermont Auvergne.
Wales are in the Plate after finishing third in Pool B to drop out of the first-tier Cup competition.
Even if Simba fail to beat Wydad, they will drop into the Confederation Cup, African club football's second tier competition, which climaxes at the end of the year.
Wilkinson has been plagued by injuries since landing the drop-goal that won England the World Cup in 2003.
Wilkinson, who kicked the winning drop goal as England triumphed in the 2003 World Cup final, had already been ruled out of Saturday's Pool A opener against the United States in Lens.
Crusaders then got their own back by doing the league double over the Frenchmen last season, although Catalans won at the Racecourse Ground in the Challenge Cup, thanks to a last-minute Thomas Bosc drop goal.
The match is a re-run of the 2003 World Cup final, which England won with an injury-time drop-goal from Jonny Wilkinson.
It means that a decade after his dramatic World Cup-winning drop goal in Sydney, Wilkinson won't have the opportunity to terrorize Australia on its own patch again.
Wilkinson, who is now back to full fitness after struggling with injuries, has good memories of facing Australia having kicked the drop-goal to secure the victory for England at the 2003 World Cup final in Sydney.
And the campaign was plunged into fresh crisis in May when bid chairman Lord Triesman was caught up in a newspaper sting suggesting Spain could drop its bid if rival bidder Russia helped bribe referees at the 2010 World Cup.
But few expected Chelsea to drop points against a Southampton team which they had demolished 5-1 in the FA Cup on January 5.
Monaghan's drop-goal and another late converted try from King capped a resounding win for the Challenge Cup holders.
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