To prove the importance of the JAK pathway, someone needed to discover a compound to test the hypothesis that inhibiting the JAK enzyme was of value in treating disease.
Researchers performed eight studies to test the hypothesis that people with higher trust in their feelings will predict outcomes of future events better than those who second-guess their feelings.
In essence, I believe this was not a failure of the drug or the mechanism but a failure of us as investigators to make sure we had sufficient disease in our population upon which to test our hypothesis--somewhat akin to trying to show one antibiotic is better than another or even a placebo, but selecting a population with no infection!