Goalkeeper Shay Given returns along with Steven Taylor, Matthew Pattison, Peter Ramage and Shola Ameobi.
Steven Taylor and Peter Lovenkrands were the only survivors of that game for the Magpies, with four youngsters handed their debuts.
The visitors had a chance to take the lead when Steven Taylor handled a cross but Kevin Nolan saw his spot-kick saved by Magpies keeper Shay Given.
That forced Hughes to bring on Ched Evans for Dietmar Hamman, and the young Welsh striker immediately forced Steven Taylor into a superb block to deflect a shot over the bar.
Newcastle are short of defensive cover with just Fabricio Coloccini and Steven Taylor available as senior professionals at centre-back, while Danny Simpson has filled in, along with Thomas Kadar and Ben Tozer in reserve.
But with two porous defences on display, there was always a chance of another before half-time and it came from the head of Steven Taylor who powered in a left-wing corner from four yards.
Newcastle defender Steven Taylor, who came into the first team at St James' Park when Speed was the side's senior professional, expressed his gratitude for the help the midfielder gave him at the club.
Loan signing Fortune, who was one of the bright sparks for the home side, collected a pass from playmaker Borja Valero before twisting away from Steven Taylor far too easily and spearing a fine strike into the bottom left corner.
Meanwhile suspension to the Magpies' regular centre-back pairing of Mike Williamson and Fabriccio Coloccini has opened the door to a first Premier League start in Newcastle colours for former Arsenal defender Sol Campbell, plus a first outing of the season for Steven Taylor.
Several other calls were aired live, including with Julia Roberts, Steven Spielberg, Taylor Swift and Stevie Wonder.
Steven Crook drove Taylor straight to Grant Hodnett at long-off, Panesar completed his pair when he edged behind and Lucas also fell for a duck, while Carl Greenidge claimed the final wicket by trapping Johan van der Wath lbw for 15.
BBC: SPORT | Cricket | Counties | Northants on course for third win
Taylor of Walter Reed Army Medical Center and Steven Nissen of the Cleveland Clinic, both raised raised questions about Cordaptive last August (see "Merck's Good Cholesterol Battle").
Worthington made four half-time changes with Jonathan Tuffey, Steven Davis, Gareth McAuley, Niall McGinn replacing Maik Taylor, Chris Brunt, Aaron Hughes and Johnson.
The speakers are picked by Steven Margolis, the former department chair, and Andrew Taylor, a political-science professor who is a columnist for Carolina Journal, a John Locke Foundation publication.
And Vytorin critics, like Steven Nissen, the prominent Cleveland Clinic cardiologist, and Allen Taylor, head of cardiology at Walter Reed Army Medical Center, had said it even before the Vytorin news broke.
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