United's win -- their third in a row -- puts them on 36 points at the top of the table, three clear of reigning champions Manchester City who dropped precious points on Saturday, drawing 1-1 with Everton at the Etihad Stadium.
Valencia finished third in the table for the third season in a row, while big-spending Malaga, owned by Qatari Abdullah bin Nasser bin Abdullah Al Ahmed Al Thani, clinched the fourth and final European Champions League qualifying spot.