Substitute Butterfield dribbled into the area and was hacked down by Reid but the penalty was not forthcoming from referee Neil Swarbrick.
Benni McCarthy's shot was well saved by Edwin van der Sar and substitute Kalinic fired into the net with the referee's assistant waving for offside.
Peter Odemwingie sent a shot bouncing wide with Hart scrambling across his goal and, after Brunt blasted over, substitute Fortune fired into the side-netting after running clear and Carlos Vela headed wide when well placed.
Cardiff were further angered when an unmarked Lisbie nodded Millwall into the lead as he glanced substitute Bouazza's excellent cross into the net.
However, the on-loan Watford midfielder netted a dramatic winner deep into injury time, skipping past substitute Paton and drilling the ball into the bottom corner of the net.
In need of cash, Dewey bluffs his way into a substitute-teaching position at an exclusive, private elementary school.
And Reading were able to wrap up the points late on when substitute Kitson ran unchallenged into the box and fired into the bottom corner of the net.
Robin Van Persie's long-range shot stung the hands of fellow-Dutchman Edwin van der Sar in the United goal, while substitute Nicklas Bentdner fired into the side-netting after a promising run.
However, the appearance of powerful Wales forward Craig Quinnell as a 60th-minute substitute instilled fresh vigour into the set-piece effort, and despite Key's battling efforts, a Cardiff victory was never in doubt.
They came close to adding a second on 70 minutes when substitute Kasper Hamalainen got into the box thanks to a fortunate deflection and Wolves keeper Hennessey had to dive low to deny him at the near post.
Kevin Foley curled Wolves back into it and substitute Steven Fletcher headed in a corner, but despite several late chances they could not force a draw.
Substitute Rafael volleyed United back into contention with a minute of normal time left - but Arsenal survived six extra minutes and an outbreak of mass anxiety at the Emirates to clinch the three points.
Diamonds substitute Jefferson Louis forced Clarke into a reflex stop from a header and Constable missed the target late on to ensure the two teams go into Monday's second leg at the Kassam Stadium on level terms.
However, they were only brief forays into the opposition half and former Latic Valencia soon added United's fifth of the night, running on to Rooney's slide-rule pass to chip over substitute keeper Mike Pollitt and into the far corner.
Second-half substitute Shane Duggan fired the ball into the roof of the net from the edge of the box on 51 minutes.
Alan Blayney saved from Andy Waterworth before substitute Ryan Deans flicked the ball into the bottom corner from Kelbie's free-kick after 72 minutes.
Accies were struggling to work their way back into the match and substitute David Louhoungou and Offiong could not find the target with half-chances.
Bayern reduced the arrears in the 47th minute when Noveski headed substitute Thomas Muller's cross into his own goal, but the home side held on.
The game looked to be petering out into a forgettable goalless draw when, one minute into added time, substitute Lappin crossed from the left flank and Holt notched his decisive header.
United sealed the victory with a third goal two minutes before full-time, when substitute Dale Hilson sent the ball into the near post from the right and Gomis touched home his second and his side's third goal.
Lazio had Brazilian midfielder Matuzalem sent off in the 69th minute for his second yellow card, harshly awarded for diving, but snatched victory two minutes into stoppage time as substitute Thomaso Rocchi stabbed home the winner from close range from a low cross.
Tottenham's desperation was evident, with high balls going into the box aimed at substitute Peter Crouch but nothing came from them.
Substitute Mikoliunas got the ball, drove into the box and fairly fizzed the ball past Smith to hand the Tynecastle side a dramatic victory.
With six minutes to go, second-half substitute Vincent Barnabas made a solo run into the Sudanese danger zone and was brought down for a penalty.
Two minutes into injury-time Saints substitute Lowndes wrapped up the points, hammering home from the edge of the box after catching United defence on the break.
However, Leicester were back on level terms when a Gallagher ball across the face of the Baggies goal was put into his own net by substitute Shorey.
With the game opening up, Joris Mathijsen was nearly an unlikely scorer for the Dutch while Spain substitute Jesus Navas saw his shot deflected into the side netting.
The visitors were level four minutes from time, however, when substitute Gomis struck a stunning strike high into the net after David Robertson's cross was only partially cleared.
Martin Paterson was carried off on a stretcher to be replaced by Jay Rodriguez, while substitute keeper Diego Penny was also called into action after an injury to Jensen.
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