The 6, 000-patient study was designed to show that AtheroGenics' drug, known by the code name AGI-1067, decreased the risk not only of heart attack, stroke and death but also of less important heart problems, including stent procedures, bypass surgery and chest pain.
Lilly's own studies show that Zyprexa doubles the risk of stroke death when given to elderly dementia patients.
Moreover, there are additional factors buttressing a need for caution: Two retrospective analyses of Medicare claims both found increased risks of stroke and death among patients using Avastin for wet AMD over Lucentis.
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After 4.8 years of follow-up a primary endpoint event (the composite of MI, stroke, and death from CV causes) occurred in 3.8% of patients in the Mediterranean diet extra-virgin olive oil group, 3.4% in the Mediterranean diet with nuts group, and 4.4% of patients in the control group.
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The label now includes a black box warning that it can increase the risk of death, MI, stroke, venous thromboembolism, thrombosis of vascular access, and tumor progression or recurrence.
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Atrial fibrillation is the most common heart rhythm disturbance, with over half a million sufferers in the UK. It increases the risk of a person having a stroke by five times and doubles the risk of death.
What if a serious form of asthma or heart condition is discovered that could cause sudden death or stroke under the extreme conditions of professional competition?
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Stroke, the third leading cause of death in the United States, often occurs without warning.
But AtheroGenics claims that the trial actually shows a statistically significant benefit in preventing the combination of heart attack, stroke and death.
Researchers found that participants taking Crestor cut their risk of heart attack, stroke and death by nearly half -- 44 percent -- compared with participants taking the placebo.
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In a new analysis published online in the Journal of the American Medical Association, Steven Nissen and Eric Topol of the Cleveland Clinic write that Pargluva doubles the risk of heart attack, stroke and death.
She did not die of a heart attack but of a stroke, according to the death certificate signed by her personal physician.
If AtheroGenics had set heart attack, stroke and death as the main goal of its study, these results could lead to approval by the U.S. Food and Drug Administration.
The study on "good" cholesterol may help doctors predict who is most vulnerable to heart disease and stroke, which are the leading causes of death in the United States.
The trial showed that patients randomized to chelation therapy had a lower risk of a combined endpoint of death, heart attack, stroke, percutaneous coronary intervention, bypass surgery or hospitalization for angina than those who received a placebo infusion.
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When Topol co-authored an influential paper on Vioxx and Celebrex in 2001, he and his colleagues looked at three certain signs of cardiovascular risk: heart attack, stroke and death.
Those who consumed the least salt had a 56 percent higher risk of death from a heart attack or stroke compared with those who had the highest consumption, even after controlling for obesity, cholesterol, smoking, diabetes, and other risk factors.
The UK has one of the highest death rates from CHD and stroke in Europe.
Tributes to her achievements poured in from around the globe, as well as from many in Britain, after the news of her death on April 8 from a stroke, aged 87.
Of the patients who received chelation, 27% had one of the following: a death, a stroke, a heart attack, a stent procedure to open a heart artery, or a hospitalization for chest pain.
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It is supposed to be much more difficult to show a benefit in the "hard events"--heart attack, stroke and death--than in the broader swath of "extra" heart problems that AtheroGenics measured in its trial.
Obuchi's stroke in April and death on May 14 caused an outpouring of sympathy for him (more than he enjoyed while alive), but none of it is rubbing off on his successor.
The primary endpoint was the time to first major vascular event, defined as the composite of non-fatal MI or coronary death, any stroke or any arterial revascularization.
This pattern held when the researchers broke out the data by specific causes of death, including heart disease, lung disease, pneumonia, stroke, diabetes, infections, and even injuries and accidents.
Hospitals are reluctant to do that now, because if the patient has had the other kind of stroke (caused by bleeding), the clot dissolver may hasten his death.
News that Hosni Mubarak, ousted last year after 30 years as despot, was near to death after a stroke in prison may be irrelevant to the outcome of the current power struggle.
Eliquis now has the unique distinction of being the only new anticoagulant to reduce stroke, major bleeding, and death versus the gold standard warfarin in atrial fibrillation patients (the largest commercial opportunity, in our view).
Liver disease, the fifth biggest cause of death in England and Wales behind heart disease, cancer, stroke and respiratory disease, comes in more than 100 forms but is most commonly associated with alcohol abuse, obesity and viral hepatitis.
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The suggestion comes a day after the death of 87-year-old Baroness Thatcher as a result of a stroke.
At the end of the study, 3.8% of the Mediterranean-diet-plus-olive-oil and 3.4% of the Mediterranean-diet-plus-nuts groups suffered a heart attack, stroke or death from cardiovascular disease.
WSJ: Mediterranean Diet of Olive Oil, Nuts, Reduces Heart Disease, Study Finds
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