Scunthorpe had the better of a low-key first half, Jonathan Forte forcing a fine stop from keeper John Ruddy.
Yet within 30 seconds Ryan Babel jinked into the penalty area to shoot low and hard, forcing a superb stop from Luton keeper Dean Brill.
Gabbiadini forced a diving stop from Blues keeper Mark Tyler before Liddle pulled off a candidate for tackle of the season after Clarke skipped round Collett, sliding full length to scoop the ball away from the striker's path.
And although Villa dominated much of the opening half, Steven Fletcher sprang into life with a crisp and technically difficult left-foot strike that drew a decent save from Brad Friedel close to the break, with the Villa keeper making another stop to deny Doyle with the rebound.
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The Londoners mounted their first serious threat seconds later when David Bentley's corner was met by Jonathan Woodgate, and when Pavlyuchenko tried to turn it beyond Brian Jensen, the Burnley keeper made a stunning stop.
And it was almost punished when Isco's rasping drive forced Dortmund keeper Roman Weidenfeller into an impressive stop.
It was the first stop of the second half for the Baggies keeper.
Their first chance came when Steve Finnan played David Edwards onside but, one-on-one, Liverpool keeper Charles Itandje made an impressive stop from the Luton forward.
And the veteran ex-Celtic keeper made a first class save to stop Hartson's close range half-volley as Celtic poured forward.
Instead of scoring into an empty net as the Everton goal keeper lay injured Di Canio opted to stop play instead.
The Hibs keeper was then at full-stretch to stop a raking 20-yard drive from Steven Davis after a neat lay-off from substitute Kyle Lafferty.
Anelka had a great opportunity to double the lead when through one-on-one with Green but the keeper spread himself well to make a fine stop.
It was a virtuoso opening from LuaLua and on 20 minutes he forced Fulham keeper Antti Niemi into a full-length stop with a dipping 25-yard free-kick.
Brown was the architect for that goal and the Scotland midfielder would have headed a third but for a smart stop on the line by United's Celtic-bound keeper.
Berbatov headed straight at Schwarzer from close range in the 13th minute, while the Boro keeper needed to be quick off his line to stop Jenas seven minutes later after a sparkling run from the midfielder.
Morrison should have made it 3-1 moments later, but Kingson saved with his legs to atone for his earlier error and the Ghanaian international keeper then closed down Odemwingie and pulled off another fine stop.
And Hammers keeper Robert Green was forced to pull off a superb diving stop to keep out Van Persie's well-struck shot following Henry's neat header.
The Aberdeen keeper came to his side's rescue again with an excellent stop to deny Miller after the striker had gone through on goal.
Black volleyed sub Peter Steele's cross to the net from a tight angle although Coleraine keeper David O'Hare appeared at fault as he failed in his attempt to stop the shot with his legs instead of using his hands.
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