Some side-effects of NSAIDs, such as an increased risk of stomach bleeding have been known for a long time.

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Sure, critics said, it might benefit some people who had a low risk of heart attacks and a high risk of stomach bleeding.

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Patients received either Arcoxia or diclofenac, and there was no difference in the number of heart attacks, strokes or death, or major stomach bleeding.

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He maintains that the right Cox-2 pill could be a boon to patients who are at high risk for stomach bleeding and low risk for heart attacks.

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Up to four per cent of patients taking NSAIDs develop serious gastrointestinal complications, including peptic ulceration and bleeding from the stomach and small intestine.

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If ingested, it causes nausea, vomiting and internal bleeding of the stomach and intestines, followed by failure of the liver, spleen and kidneys, and death by collapse of the circulatory system.

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However, NSAIDs can irritate the stomach lining, and cause ulceration which can lead to bleeding and infections.

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Esophagitis can also trigger esophageal bleeding or ulcers after frequent exposure of the esophagus to stomach acid.

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