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The clinical trial followed a total of 842 patients until 608 of them had died in order to get statistical power.
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Mariel Jessup of the University of Pennsylvania noted that the study did not really have the statistical power to make such conclusions.
FORBES: Magazine Article
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This massive numbers allowed the researchers to exclude smokers and people who had already been diagnosed with heart disease or cancer, and still have strong statistical power.
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One reason for BMI's tenacity can be seen in the availability of so many patients for the JAMA study, enough to provide the statistical power to detect 6% differences in mortality among groups.
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What we need is a construct with teeth, an established network of industry-independent researchers (not contractors) equipped to evaluate trial design, statistical power, data analysis, and interpretation, not as regulators but as contributors to final research publications.
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The authors did this comparison because while randomised trials of aspirin could clearly establish the risk of colorectal cancer, several other solid cancers, and of metastasis, these trials lacked the statistical power to establish effects on less common cancers and on cancers in women.
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Pujols has gradually restored our trust in the statistical production of modern day power hitters.
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Power-law patterns are similar to the statistical distributions of seismic activity, which inspires hope of predicting both types of calamity.
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