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Nadal and Argentine partner Juan Monaco lost the doubles final to Italians Potito Starace and Paolo Lorenzi.
CNN: Knee injury continues to 'bother' Rafael Nadal
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Nadal will be seeking the eighth doubles title of his career when he and Monaco play Italians Paolo Lorenzi and Potito Starace.
CNN: Rafael Nadal overcoming his 'bad feeling'
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Three Italian players - Potito Starace, Daniele Bracciali and Alessio di Mauro - were hit with suspensions last year for betting on matches.
BBC: CHOOSE A SPORT
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The Czech Republic are through to the quarterfinals after Tomas Berdych and Radek Stepanek beat Italy 's Daniele Bracciali and Potito Starace 6-3, 6-4, 6-2 in Ostrava.
CNN: Federer loses again as Swiss crash out to U.S.
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Swiss star Federer should have another easy ride in the second round when he faces unseeded Russian Evgeny Korolev, while Spaniard Nadal takes on another Italian in Potito Starace.
CNN: Federer and Nadal cruise as nemesis Soderling crashes out
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Fourth seed David Ferrer defeated Italian Potito Starace 4-6, 7-5, 6-2 in what he called "a very physical match" and 2004 champion Tommy Robredo overhauled Russian Igor Andreev 4-6, 6-2, 6-3.
BBC: Nadal handed bye into semi-finals
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Federer, whose return to action in Madrid after a two-month break ended with a third-round loss to Japan's Kei Nishikori, also eased through to the third round after beating Italian wild card Potito Starace 6-1 6-2.
CNN: Djokovic eases ankle fears with comfortable win in Rome
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Federer had only just flown back to Europe following his five-set defeat by Juan Martin Del Potro in Monday's US Open final, but beat Simone Bolelli on Friday and then secured the decisive third point with a 6-3 6-0 6-4 win over Potito Starace on Sunday.
BBC: Spain and Czechs through to final