After its fourth drug failure this year, Merck has two medicines in late-stage development.
Vertex plans to conduct additional studies of VX-661 to further evaluate its potential for late-stage development, pending regulatory discussions.
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Primary end-points are needed for definitive (Phase 3) proof of efficacy, but they are the most pernicious concept in early stage development.
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But I was not prepared for the broad criticism of the companies that took the chance to advance bapi into late stage development.
This productivity surge is supported by the large number of experimental medicines now in late stage development, especially in the area of oncology.
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But there appears to be only one new cholesterol-lowering pill in mid-stage development, and its a drug that Pfizer ate up and spit out.
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This more collaborative model is being applied to the high-risk innovative early stages of drug discovery, with companies taking on the highly expensive later stage development.
One of the really attractive aspects of investing in the mid-cap area of the market is, we have the opportunity to look for companies that are beyond the trials and travails of early-stage development and infancy.
At Index Ventures, we have modelled the early stage development process (up to proof of clinical concept) on the presumption that the majority of the risk in a discovery programme is not only unknown but it also unknowable (ahead of testing in man).
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The split ends a decades-long partnership that appeared to unravel after Lilly signed a deal earlier this year with Boehringer Ingelheim to jointly develop and sell several diabetes compounds that are in mid- and late-stage development, including a Boehringer oral diabetes agent known as linagliptin.
It said the guidance is in an early stage of development and had not been finalised.
The next stage of development, says Mr Walker, will be to add some level of intelligence.
In markets like India, e-commerce, a key online advertising driver, is at an earlier stage of development.
And only if the start-up has reached a further stage of development does it get equity investment.
New research also surfaced, implying that 20somethings are in the throes of a new stage of development.
Or that they have no relevance in countries where financial markets have not reached that stage of development?
ChevronTexaco is buying Unocal at a prime time, considering that the riskiest stage of development in Azerbaijan--exploration--is over.
While China is already the second-largest economy in the world, it is still in an embryonic stage of development.
Chinamex is investing 10 billion Chinese Yuan in the first stage of development.
Its sea-based rival is at an earlier stage of development, with the first intercept planned in about a year.
Femtosecond lasers are beginning to be used in medicine, although such applications are at an early stage of development.
They can be pioneers in helping our society move to the next stage of development in a global economy.
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One of them is the increase in the number of collaborators and the numerous interactions among them, across each stage of development.
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But it is still a discipline at an early stage of development.
Chinese companies are past the point of having to copy products or technologies in order to move to a higher stage of development.
Rising borrowing is expected in economies at this stage of development, and many of the companies have experience lending in markets such as these.
China and others are entering the tricky middle-income stage of development in which the big advances from absorbing rich-world technology start to run out.
To get human retinal cells at the same stage of development, however, would involve taking stem cells from a foetus during the second trimester of pregnancy.
If it seems hard for anyone to make himself heard amid this cacophony, that is largely because e-commerce is at such an early stage of development.
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