For all Genzyme's stability, its gene therapy research might represent a kind of Achilles' heel.

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"We want to manage the cost of desktop operations and increase stability, " says Gene Dickamore, business systems manager for Arup Labs, a medical reference laboratory.

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Famed academics Gene Fama and Ken French enjoy the stability of book value and this leads them to high book-to-market companies (high BtM).

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