Wigan had N'Zogbia sent off late on but Squillaci headed into his own net to give the home side a deserved point.
Robin van Persie nodded against the bar before a horrendous mix-up between Manuel Almunia and Sebastien Squillaci gave Peter Odemwingie a simple finish.
Meanwhile, France international Sebastien Squillaci will make his Arsenal debut in defence because Thomas Vermaelen has been sidelined by an, ahem, Achilles injury.
Anelka robbed the hesitant Sebastien Squillaci, and even though the striker rounded Fabianski the angle was too acute and the finish rolled agonisingly wide for Chelsea.
The hosts led when Peter Clarke diverted Nicklas Bendtner's strike into his own net, before Sebastien Squillaci was sent off for a block on Jack Hunt.
It leaves Laurent Koscielny and Sebastian Squillaci as the Gunners' only fit senior central defenders, with Thomas Vermaelen still out because of an Achilles tendon problem.
Johan Djourou and Denilson are available to face Bolton on Saturday after injury, while Sebastien Squillaci could be involved for the first time after his move from Sevilla.
Arsenal then went for the jugular and Carson got down well to save Clichy's low shot, while at the other end substitute Marc-Antoine Fortune saw a strike blocked by Squillaci's last-ditch challenge.
Squillaci looked set to clear Youssouf Mulumbu's long ball forward only for Almunia to come needlessly racing off his line, seemingly confuse his team-mate and allow the Nigerian to double his side's lead.
The young defender dispossessed Arshavin for the first time in the game and set on a rampaging run through the Gunners' midfield, which ended when he was blatantly body-checked by last man Squillaci, who was duly sent off.
After dominating the first 40 minutes of the match, Arsenal found themselves on the back foot following Squillaci's deserved dismissal and an equaliser from Lee - the 32-year-old striker's first goal for Huddersfield on his 26th appearance for the club.
It was not a day free of concerns, however - Wenger admitted his side's defence looked "vulnerable" and also revealed defender Laurent Koscielny had suffered concussion after a clash of heads with team-mate Sebastian Squillaci in the build-up to Fulham's goal, scored by Diomansy Kamara.
应用推荐