Mr Jacobs collaborated with trendy artists like Stephen Sprouse, Julie Verhoeven and Takashi Murakami to spruce up the company's traditional pattern and logo.

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"It's hard to tell in advance what effect a principle will have, " says the FASB's scholarly vice chairman, Robert Sprouse, a former Stanford University professor.

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"Literally every pharma company out there has some idea about how to get early onset, " says Pfizer neuropharmacologist Jeffrey Sprouse, team leader for the fast-acting antidepressant program.

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Most recently, Marc Jacobs engaged Takashi Murakami, Richard Prince and Stephen Sprouse to work with the Vuitton monogram for things like bags, window displays and art installations.

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Sprouse and others theorized in the early 1990s that drugs that blocked these self-defeating autoreceptors could create a faster impact by causing an immediate, long-lasting flow of serotonin that would lift a patient's mood in days.

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