Wales have beaten the Springboks just once in their history, and have never triumphed on South African soil.
After the Springboks game Wales face Canada, New Zealand and Australia on successive weekends.
But playing against the green and gold of the Springboks usually sharpens the senses.
But Springboks vice-captain Victor Matfield said his team-mates needed to adapt to the referee's law interpretations.
The Springboks endured a record 53-3 defeat at the hands of England at Twickenham on Saturday.
Wales play the Springboks in Durban on Saturday, 7 June and in Pretoria a week later.
But judging on their performance against the Springboks, a win is far from guaranteed.
Erasmus was ruled out with an ankle injury suffered in the Springboks' 18-13 victory on Saturday.
Springboks doctor Craig Roberts said that the players had been taking medication for flu symptoms.
He was recalled to the bench to face the Springboks, but has suffered a torn thigh muscle.
Edinburgh prop Jacobsen has shaken off a shoulder problem sustained in the battling win over the Springboks.
Morne Steyn's injury-time penalty earned the Springboks a dramatic 28-25 victory and sealed a 2-0 series win.
The Springboks have also had two players suspended after the two games of the tournament so far.
Springboks coach Jake White said he had been encouraged by the way his side started the game.
Montgomery, Habana, Pietersen then all crossed late on as the Springboks finished the contest in dominating style.
The former Springboks centre backed his players to improved when they take on France, Italy and Ireland.
O'Gara replaces Jonathan Sexton at fly-half after making a hugely positive impression as a replacement against the Springboks.
So why was the prevailing match-day emotion that hung over Cardiff after the 29-25 Springboks defeat simply apathy?
Juan de Jongh and Jongi Nokwe crossed to send the under-strength Springboks into half-time with a 12-point lead.
The Wasps forward was sin-binned for putting his knee into the back of Springboks scrum-half Fourie du Preez.
"We are ready to write a new chapter in the history of Italian rugby, " said ex-Springboks coach Mallett.
Two Springboks have been sin-binned in recent games between the teams while he says All Blacks are going unpunished.
Springboks coach Rudolf Straeuli has been given a vote of confidence, despite his side's disastrous November tour of Europe.
Jacobs grabbed a second from Montgomery's deft inside pass, but the Springboks were booed off after another dispiriting defeat.
Phil Godman also missed two penalty attempts against the Springboks, one from close range right in front the posts.
Burger was cited for a dangerous tackle on Samoa scrum-half Junior Polu in the Springboks' 59-7 win on Sunday.
De Villiers believes the British tour will play a key part in the Springboks' preparations for the Lions tour.
On the morning of the match, he is still too bitter about a lifetime of injustice to support the Springboks.
The coach added that he was always confident that his side would recover from their awful start against the Springboks.
James is replaced in the squad by Bulls full-back Zane Kirchner, who will join the Springboks in Cardiff on Thursday.
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