In the closing stages Rangers launched attack after attack in the direction of Speroni.
Watford missed a chance to fight back on the stroke of half-time when Speroni saved Danny Graham's penalty.
De Boer set Arveladze up for a drive and it needed a spectacular Speroni tip over to deny him.
Speroni tipped away a Boyd effort as Palace's quest to climb back up the table began with an encouraging win.
Dele Adebola had the best chance of the first half but his header was superbly saved by Palace keeper Julian Speroni.
After Palace keeper Julian Speroni saved at full-stretch from Lee Frecklington's snap shot, the home side quickly began to exert pressure.
Speroni then denied Varney with an excellent save after the Wednesday forward shrugged off two Palace defenders before shooting from across goal.
The ball was quickly moved on to the unmarked Arveladze, who was able to take a couple of touches before drilling past Speroni.
Victor Moses opened the scoring after Julian Speroni's clearance caused havoc in the visiting defence before Alan Lee nodded home Danny Butterfield's cross.
But Dean saw no infringement, and Clarke raced into the box before brilliantly curling his right-foot strike beyond the despairing dive of Speroni.
Only an excellent save from Speroni kept out Adebola's header after he had been found by Bradley Orr's superb cross from the right.
Agbonlahor was then foiled by Speroni in a one-on-one, before Young saw his effort brilliantly tipped around the post by the impressive Palace keeper.
Gavin Rae tripped Arteta 30 yards in front of goal and Ricksen forced a good save out of Julian Speroni at the expense of a corner.
The best early chance fell to Agbonlahor, who expertly spun past Claude Davis and burst into the box only to see Speroni parry his low shot.
The hosts started in blistering fashion as Palace keeper Julian Speroni kept the visitors in it with two smart stops from Carew and another from Young.
Palace keeper Julian Speroni then had to produce a great save to deny Trotter, who also went close with a looped header that cleared the bar.
Palace initially held out, with Speroni producing a cracking save to tip the ball over after Richard Dunne flicked on a free-kick and Carew nodded goalwards.
Nigerian teenager Christian Obodo, Perugia's most impressive player, then forced Speroni to leap and tip away his fierce 22-yard drive as the home side finished strongly.
The Dundee defence were able to block Margiotta first shot from inside the area but the rebound favoured the striker and his second attempt beat Speroni.
The brave but tiring visitors had no riposte and Villa continued to pile forward, with Speroni performing more heroics to superbly tip over Stewart Downing's 20-yard drive.
Palace ended the first half on the attack, but it was Bristol City who found the momentum in the minutes after the restart without really testing Palace keeper Julian Speroni.
The tempo did not let up after the break, with John Carew - on for Heskey - testing Speroni with a snap-shot on the turn from the corner of the six-yard box.
The Hornets were handed a golden opportunity on the stroke of half-time when Lee brought down Henri Lansbury in the penalty area, but Speroni produced an outstanding save to keep out Graham's spot-kick.
Jermaine Johnson was a lively presence on the right flank and forced a decent save from the excellent Julian Speroni, who also held a weak Mark Beevers header and a poor Luke Varney strike.
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