"It was incredibly disappointing, " laments retired SmithKline executive Martin Rosenberg, who led the effort.
"This vaccine will have a huge impact, " predicts Jean Stephenne, chief of Glaxo- Smithkline's vaccine unit.
SmithKline Beecham's chief scientific officer, George Poste, speaks of pharmacogenomics as the savior of the industry.
Diadexus inherited from SmithKline the new heart risk factor, called Lp-PLA2, or lipoprotein-associated phospholipase A2.
Among the first to recognize this potential was George Poste, former chief scientist for SmithKline Beecham.
The Supreme Court will decide two related, but different questions, in the SmithKline case.
In 1996 SmithKline Beecham vowed to discover two new antibiotic classes by 2003.
The new Glaxo-SmithKline depended for its success on the collaboration of scientists and managers from both companies.
Intriguingly, even the apparently disastrous collapse of Glaxo-SmithKline hints that managers might be behaving more like shareholders.
Chief Executive StanleyCrookeStanley Crooke, 60, headed drug development at Smithkline Beckman and anti-cancer research at Bristol-Myers Squibb.
Now, it is losing market share rapidly to competitors such as Pfizer's Zoloft and SmithKline Beecham's Paxil.
SmithKline, over whether drug reps should be covered under a specific exemption for salespeople under federal labor laws.
WHO, which is starting, in collaboration with Merck and SmithKline Beecham, a massive drug-donation programme for the disease.
In 1997 he helped set up Diadexus as a venture between SmithKline and Incyte (each still owns a 20% stake).
Most drugs on the market today target such receptors: SmithKline Beecham's ulcer medicine Tagamet, and American Home Product's hypertension drug Inderal.
The hastily announced drug merger between Glaxo Wellcome and SmithKline Beecham collapsed when neither boss was prepared to pay second fiddle.
But when SmithKline researchers screened their compound collection against the novel proteins from staph and strep bacteria, they found few good leads.
The Glaxo-SmithKline example may seem extreme, but in many ways was typical.
Glaxo and SmithKline may prove to be the exception to this rule.
About the only sympathetic listener he could find was John Horton, a parasitologist at SmithKline and a passionate hunter of affordable cures for tropical parasites.
Two new giants were created in the drug industry : Glaxo Wellcome announced a union with SmithKline Beecham, and Pfizer completed its acquisition of Warner-Lambert.
Early experiments suggested that an antisense drug could precisely target cancer cells, but Crooke was unable to reproduce this nascent work in his SmithKline lab.
That the biggest merger ever was hatched in just ten days should encourage shareholders in Glaxo and SmithKline to look closely at the small print.
In Britain, there is a well-worn path between drug giants such as SmithKline Beecham and Glaxo Wellcome, and executive and non-executive slots on biotech boards.
SmithKline hopes to test the vaccine at its labs in Belgium.
Avandia was invented in the laboratories of Smithkline Beecham, a Glaxo predecessor, two decades ago as one of a class of medicines meant to treat diabetes.
Wyeth-Ayerst, Abbott Laboratories, Merck, SmithKline Beecham and Pfizer have invested heavily in the field, either on their own or by buying or teaming up with smaller, entrepreneurial research outfits.
Colin Witheat, SmithKline's risk manager, says he can halve operating costs by cutting the fees he once paid an insurer to front business around the world.
He instead joined SmithKline Beecham, the predecessor of GSK, in 1996 for the purpose of picking up the management experience he needed to head the next startup.
In the fight against prostate cancer, bioinformaticians at SmithKline used their desktop computers to compare genetic data taken from a normal prostate with genetic data taken from a cancerous one.
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