And versus conventional small molecules, they offer improved selectivity and larger binding modes (useful for PPIs), among others.
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This means genes can be re-programmed with small molecules that mimic these environmental factors, what is called molecular medicine.
The researchers are now screening small molecules to look for those that might increase SNX27 production or function in the brain.
One of the ways functional genomics works is to use models to identify proteins or small molecules that interact with other proteins.
One big advantage is the company's longstanding focus on small molecules.
Agios also is likely, based on its existing competencies, to focus on making small molecules, not the expensive proteins that currently dominate the rare disease space.
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Second, biologics are really difficult to copy, and thus even after the patents expire, knock-off biologics (biosimilars) are far less a threat than knock-off small molecules (generics).
Meanwhile, researchers at the French Petroleum Institute have found that they can perform another industrially important reaction linking small molecules called olefins together more cheaply in ionic solvents than in conventional ones.
In its first two rounds, the company aspired to demonstrate that its technology would work at least as well as the existing method of testing for DNA, proteins, and small molecules.
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He was also determined to use a stem-cell based approach: By marrying what he did in industry with what he wanted to do in pure research, to pursue drug discovery and small molecules.
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We take a million of these small molecules--they are not drugs but the starting points for drugs--and mix each one of those prototype drugs with a protein we have in a test tube.
Small molecules in nature, mostly what are called polyphenols (resveratrol, quercetin, catechin, curcumin, others), as found in concentrated form in red wine, can cross the cell wall and enter the cell and influence genetic machinery.
If future experiments prove that such genes are essential to the bacterium's happy existence in the gut, then small molecules might be administered to block this pathway and make El Tor's life rather more difficult.
The molecules are then sorted according to their length by using an electric current to drag them through a gel (small molecules move faster than big ones) and the order of the colours in the gel is read off, using a laser.
But their technology was based on the luminescent abilities of small organic molecules--single molecules--in contrast to the large ones--chains of molecules--Friend utilized.
Small organic molecules won't dissolve in a liquid and so must be deposited onto a screen using a process similar to etching a standard computer chip.
The paper in PNAS suggests that the actual positioning of the motifs is associated with small RNA molecules that are involved with a process called post-transcriptional gene silencing (PTGS).
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By first splitting the molecules into very small lines and then using an equally rare nanoimprinting technology to put them into circular tracks, HGST can create platters with a 10 nanometer-wide bit pattern that's twice as dense as current hard drives.
So far, though, this has been experimentally limited to small particles and a few tiny molecules.
At such small scales, the behaviour of molecules depends on their size.
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Get small enough--down to molecules and atoms--and everything changes.
We make microprocessors so small that their walls are bumpy with molecules and that can perform ten billion computations in a second.
Instead of medicines made from small, easy-to-manufacture molecules, biotech drugs were proteins or antibodies--big messy molecules of the kind found in our bodies.
In the right conditions, an emulsion of these molecules will organise itself into small spheres, known as vesicles, that contain part of the liquid the phospholipids were suspended in.
Except for the drawings of molecules on its doors, the small Chevy Equinox SUV looks like an anonymous, run-of-the-mill General Motors vehicle.
These, in case you did not know, are small electric motors whose shafts rotate on bearings made of gas molecules.
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And what happens is that the carbon in molecules gets re-ordered and this happens in very small domains, less than micron-sized areas.
And they might be more lucrative than generic versions of small-molecule drugs, if the complexity of developing these larger molecules limits competition.
They are carried out at a scale so small that room temperature induces wigglings of the AFM's constituent molecules that would blur the images, so the apparatus is kept at a cool -268C.
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Like alcohols, fatty acids are molecules that have lots of hydrogen and carbon atoms, and a small amount of oxygen (in their case two oxygen atoms, rather than one).
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