• Typically, it has taken pharmaceutical companies four or five years to go from gene target to small molecule.

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  • For small molecule drugs, the lifeblood of drug companies like Pfizer and Merck, it is one in 25.

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  • Therefore, development costs will be higher and there will be far fewer biosimilars developed than generic versions of small molecule drugs.

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  • Second, large drug companies are trying to avoid traditional small molecule drugs that will face large generic uptake after their patents expire.

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  • We take a protein, and a small molecule, and the small molecule binds with the protein and changes the activity of the protein.

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  • And, small molecule pharmaceutical developer Myrexis ( MYRX) said its board has appointed interim CEO and CFO Robert Lollini to take the CEO post permanently.

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  • Now the company is focusing on testing whether can improve side effects and usefulness in small molecule drugs, including ones for several old chemotherapy medicines.

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  • Among their projects: developing a hybrid anticancer compound that combines an antibody with a cancer-targeting small molecule and using algae to quickly grow human antibodies that zero in on herpes.

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  • "The next step is to be able to industrialize this process of finding a small molecule inhibitor, as Millennium seems to have done, " says Banc of American Securities analyst James Reddoch.

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  • So how do you find the small molecule?

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  • On the FDA's Fast Track and in phase III testing is the company's BAY 43-9006, a small molecule RAF kinase and VEGF inhibitor that inhibits tumor growth for patients with metastatic renal cell carcinoma (advanced kidney cancer).

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  • The big bottleneck in going from gene to drug is having the chemical know-how to create a small molecule drug, the kind of chemical that can be produced very cheaply and sold for a lot of money.

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  • The Genzyme acquisition is really a bet that in the future drug companies will need stable businesses like vaccines and consumer health that are insulated from the sudden drops of sales that happen with traditional small molecule drugs in the U.S. market.

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  • While Omontys was a different molecule than either Epogen or Aransep (and a fairly simple molecule, one that is regulated by FDA as a small molecule and not as a biologic) there could be some subtle, long-term lessons for FDA around issues of immunogenicity, hypersensitivity, and similar principles that translate to how FDA reviews biosimilars.

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  • Kodak's small-molecule OLEDs, which make better use of current manufacturing technology, proved quicker to develop.

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  • Protein drugs like Enbrel are much more expensive to make than traditional small-molecule drugs, and Thousand Oaks, Calif.

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  • That's why small-molecule generics are so much cheaper in America than they are in Canada and western Europe.

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  • Its secret: combining gadolinium in a small-molecule shell form that attaches to albumin, a blood protein that carries hormones throughout the body.

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  • It is in the process of completing the acquisition of Allos Therapeutics (ALTH), whose drug, Folotyn, is a small-molecule therapeutic for cancer.

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  • The 657-employee company is developing a small-molecule drug to fight advanced solid tumors, metastatic brain tumors and blood cancers, as well as refractory, ovarian and prostate cancers.

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  • Similar expirations have spawned a large generic industry around so-called small-molecule drugs and the same can occur for genetically engineered products that are proprietary and highly profitable today, Konski said.

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  • Because most small-molecule drugs can be manufactured with easily replicable chemical processes that lead to a largely reproducible drug formulation, the clinical trial data that supported approval of the original version can be relied upon for the generic versions.

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  • If Turin wanted to work on this using his algorithm, he'd start with one of patchouli's components--say, a molecule that smells earthy or woody--and try varying its structure in small ways.

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  • He then developed an initiator molecule for each stretch that would make thousands of copies of that stretch if exposed to a small sample of it.

    ECONOMIST: DNA tracking

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