These drugs were tested in small patient populations who have a specific genetic defect that the new drug was designed to repair.

FORBES: Is Big Pharma Utilizing Too Many Resources on Potential Blockbusters?

My left arm is a short stub with a small hand and three fingers, reminiscent of a thalidomide defect.

NPR: I Am Not My Body

Because their dominant culture of 99% defect-free operational excellence squashes any attempts at innovation just like a Sumo wrestler sitting on a small gymnast.

FORBES: Creating An Innovation Culture: Accepting Failure is Necessary