Noticing the circadian pattern of Charles B's depression, Dr Wehr asked him to get through a night without sleeping, and then to increase his nightly sleep only gradually, so that for almost a week he was awake during those crucial early-morning hours.

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It hasn't been an easy decision and sleep was a stranger to me for much of last week and this, I'm told, I will probably have to get used to.

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For better sleep, don't just set a morning alarm -- set a bedtime for both the week and the weekend and keep to it.

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